MUSICURE RESEARCH

Research and clinical studies

More than 20 years of development and the study of results from research with this music form the foundation for the creation of MusiCure, and the music is used today in a wide variety of different types of treatment and research projects in many countries. Since 2003, independent researchers and professional therapists from several countries have conducted medical studies with MusiCure. The results of these studies and controlled trials are today published in several international medical journals, including: Heart & Lung - The Journal of Acute and Critical Care , European journal of Cardiovascular Nursing, Intensive and Critical Care Nursing, Pediatric Anesthesia etc.
Examples of published research include studies with MusiCure for heart surgery patients at Örebro University Hospital, Sweden, where physiological measurements also showed significant fluctuations in hormone balance, with reduction of stress hormone and increased production of oxytocin in the 'music group' patients, compared to the 'control group'. Also from Sweden, studies with children in day surgery have shown a great reduction in use of morphine for the children who listened to the music. Research in the United States has also shown decreased feelings of anxiety in patients who underwent cardiogram studies and listened to music during the procedure - to mention just a few selected examples.

The published articles describing research studies using MusiCure as 'music medicine' and therapy shows

• Significantly reduced feelings of stress, anxiety and pain
• A decrease in use of medication and drugs (tranquilizers, morphine, sleeping pills, etc.)
• Lowering of the body’s production of hormone cortisol (stress hormone)
• Increase in production of hormone oxytocin ("peace/love hormone")
• Generally – an increased sense of calmness, well-being, motivation and inspiration.

REFERENCES

The research in the effect of the MusiCure music is mainly performed with both ‘music groups’ and ‘control groups’ and include both quantitative and qualitative studies, subjective questionnaires and interviews, as well as purely physiological measurements on the patients.

Internationally published articles describing research with MusiCure

Music interventions in patients during coronary angiographic procedures: A randomized controlled study of the effect on patients’ anxiety and well-being. by Birgit P. Weeks, Northwest Hospital & Medical Center, Seattle, Washington, USA, and Ulrica Nilsson, Department of Anaesthesia and Intensive Care and Centre for Health Care Sciences, Örebro University Hospital, Sweden. Published in European Journal of Cardiovascular Nursing (2010)
School-aged children’s experiences of postoperative music medicine on pain, distress, and anxiety. Authors: Stefan Nilsson RN, MSC Department of Paediatric Anaesthesia and Intensive Care Unit, The Queen Silvia Children’s Hospital, Sweden, co-authors: Eva Kokinsky MD, PhD, Ulrica Nilsson RNA, PhD and Karin Enskär RN, PhD. Published in Paediatric Anaesthesia (2010)
Soothing music can increase oxytocin levels during bed rest after open-heart surgery: a randomised control trial. Author: Ulrica Nilsson Assisting Professor, RNA and PhD at the Centre for Health Care Sciences at Örebro University Sweden. Published in Journal of Clinical Nursing (2009)
Patients’ perception of music versus ordinary sound in a post anaesthesia care unit: a randomised crossover trial. Malmoe University Hospital, Sweden, Authors: Ann-Charlotte Fredriksson, Leif Hellström, Ulrica Nilsson. Published in Intensive and Critical Care Nursing (2009)
Effects of Non pharmacologic Distraction Methods on Children's Postoperative Pain - A Non-matched Case Control Study. By Susanne Winther Olsen 1, CharloPe Rosenkilde 2, Jørgen Lauridsen 3, Dorthe Hasfeldt, OUH Denmark Published in Journal of PeriAnesthesia Nursing, Jan. 2020
Positive effect of MusiCure on patients undergoing bronchochoscopy - A randomized controlled trial - by Elisabeth Jeppesen, Carsten Michél Pedersen, Klaus Richter Larsen, Anne Rehl, Karen Bartholdy, Vibeke Backer. Bispebjerg Hospital Published in European Respiratory Journal, 2016
Perioperative music may reduce pain and fatigue in patients undergoing laparoscopic cholecystectomy. Authors: Graversen M. and Sommer T. Department of Surgery, Randers Region Hospital, Randers, Denmark. Published in Acta Anaesthesiologica Scandinavica 2013
The effect of music intervention in stress response to cardiac surgery in a randomized clinical trial. Author: Ulrica Nilsson Professor, RNA and PhD at the Centre for Health Care Sciences at Örebro University Sweden. Published in Heart & Lung – The journal of Acute and Critical Care (2008)
Designed sound and music environment in post anaesthesia care units–a multicentre study of patients and staff. Authors: Thorgaard P, Ertmann E, Hansen V, Noerregaard A, Hansen V, Spanggaard L. Published in Intensive and Critical Care Nursing 2004
The effect of music on heart rate and motion artefacts during gamma camera acquisition for myocardial perfusion scintigraphy. (Internationally presented Poster from Herlev University Hoapital) By: Pulawska T., Gerhardt M., Sondergaard, S. and Zerahn,B.
Meaning, Power and Exoticism in Medicinal Music: A Case Study of MusiCure in Denmark. Author: Tore Tvarnø Lind – Tore Tvarnø Lind is Assistant Professor in ethnomusicology at the Department of Arts and Cultural Studies, University of Copenhagen.2.November 2007. Published in Ethnomusicology Forum 2007.
Specially selected music in the cardiac laboratory—an important tool for improvement of the wellbeing of patients. Authors: Gøtzsche B, Henriksen BB, Pedersbaek G, Thomsen I. Published in European journal of Cardiovascular Nursing (2003)
Implicit Processing of Visual Emotions Is Affected by Sound-Induced Affective States and Individual Affective Traits. by Tiziana Quarto, Giuseppe Blasi, Karen Johanne Pallesen, Alessandro Bertolino and Elvira Brattico – Published at PLOS ON (2014)
Effectiveness of music interventions for women with high anxiety during coronary angiographic procedures - a randomized controlled study. Author: Ulrica Nilsson, Professor, PhD & RNA, Örebro University, Sweden. Published in European Journal of Cardiovascular Nursing 2012
Randomized Controlled Trial on the Impact of Music Therapy During Cardiac Catheterization on Reactive Hyperemia Index and Patient Satisfaction: The Functional Change in Endothelium After Cardiac Catheterization, With and Without Music Therapy (FEAT) Study. Author(s): Lindsay Ripley, BS; Georgios Christopoulos, MD; Tesfaldet T. Michael, MD; Mohammed Alomar, MD; Bavana V. Rangan, BDS, MPH; Michele Roesle, RN; Anna Kotsia, MD, PhD; Subhash Banerjee, MD; Emmanouil S. Brilakis, MD, PhD. Published in Journal of Invasive Cardiology (2014)
The effect of music intervention in relation to gender during coronary angiographic procedures: a randomized clinical trial. Authors: Nilsson U, Lindell L, Eriksson A, Kellerth T. Department of Cardiothoracic Surgery, Orebro University Hospital, Sweden. Published in European Journal of Cardiovascular Nursing (2009)

Review and other articles:

Music as an aid for postoperative recovery in adults: a systematic review and meta-analysis – a review article, by Jenny Hole, Martin Hirsch, Elizabeth Ball and Catherine Meads. Published August 13. 2015 in The Lancet (with reference to 5 studies using MusiCure by Niels Eje).
The Effects of Perioperative Music Interventions in Pediatric Surgery – by Marianne J. E. van der Heijden, Sadaf Oliai Araghi, Monique van Dijk, Johannes Jeekel and M. G. Myriam Hunink. Published August at PLOS ONE (2015) (with reference to the study: School-aged children’s experiences of postoperative music medicine on pain, distress, and anxiety, by Stefan Nilsson et al.)
Articles published in Nordic Journals and by Musica Humana Research, and Bachelor projects:
Treatment with MusiCure of psychiatric patients suffering from anxiety – a pilot study. Author and project coordinator: Torben Egelund Soerensen, Candidate in Music therapy, Psychiatric Department, Horsens Hospital, Denmark. Supervisor: Joergen Tybjerg, MD, Consultant Psychiatrist, Psychiatric Department, Horsens Hospital, Denmark. Published in Psykiatrien – Årsskrift 4 (2005)
Designed sound environment for heart patients before and after invasive procedures. Author and study leader: Bitten Gøtzsche, Ward Nurse, Cardiac Laboratory, Department of Cardiology, Aalborg University Hospital, Denmark. Published 2010
Can music improve patients’ mental wellbeing perioperatively? By Marianne Jungersen, Surgical Nurse, Day surgery Department R, Ullevaal University Hospital, Norway Published in the Norwegian nurse sheet “Overview” 2006, and at Musica Humana Research
Music intervention among children with autism spectrum disorder and sleeping difficulties. By Susan Gulstad, Education Consultant, Egebakken – school for children with autism, Denmark Aalborg University Hospital. Published 2006
Music for patients in intensive care and recovery wards at Odense University Hospital Music therapy during the recovery process after major surgical procedures. By Vibeke Hansen, Specialist nurse at VITA, Odense University Hospital and Anni Nørregaard, Clinical nurse teacher, ICU V, Odense University Hospital. Published by Musica Humana 2004
Summary of project Ataraxia. By PhD student, music therapist, teacher Karin Schou. A project at Aalborg University Hospital, Aalborg, Denmark, describing the effect of music on pain, nausea, well being and anxiety in a post anaesthetic care unit. Number of patients: 200 - Published November 2003 by Musica Humana
Music reduces anxiety and discomfort during dialysis treatment. By Hanne Agnholt, clinical nurse, and nurses Birthe Gross, Inger Bjerre Rosa, Fantahun Wassie Ketema, and Birgitte Schantz Laursen, senior researcher. Published in journal ‘Dialäsen’ (2011)
Reduction of anxiety in heart patients using existential psychology & music medicine, Bachelor student project at the Danish Nursing school, by Morten Thomas Guldager. Published 2010
Musikkens muligheder (music options) – a bachelor project about the use of music for children with cancer, by Rose Marie Majlund Kent, Department of Arts and Cultural Studies at Copenhagen University. Published 2013
Musikpuden (The music pillow) – en kvalitativ undersøgelse af depressive patienters oplevelse af velvære (a bachelor project about treatment with MusiCure music and MusiCure Pillow to patients suffering from depression). by Paula M. Ihlen, Amalie Vincensen, Zenia Hansen og Camilla E. Hess – University College Sjælland – Campus Næstved 2016
Neurosurgicel Intensive Care patients and the effect of music therapy (Neurokirurgisk intensive patienters effekt af terapeutisk brug af musik). Et bachelorprojekt fra 2007 af Søren Ebdrup, (in Danish).
Our Musical Brain. By Lars Heslet, Professor, Dr. Med. Head of Intensive Care Section 4131, Danish State Hospital, Published by Musica Humana November 2003
Medicine and Music - The use of specially designed music in Intensive Care Section 4131, Copenhagen University Hospital, Denmark By Lars Heslet Professor, Dr. Med. Head of ICU 4131, Rigshospitalet, Published by Musica Humana June 2003

MusiCure in Healthcare ApS

Research and clinical studies

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